Eighty percent of patients first go to their doctor because of blood and/or clots in the urine. Other urinary signs include increased frequency of urination, intermittent hesitancy, urgency, bladder spasms and pain or burning with urination (dysuria), difficulty passing urine and recurrent infections in the urinary tract. There are many more common reasons for such symptoms, however, such as an enlarged or inflamed prostate, stones, injury and various infections.
Late symptoms—loss of weight or appetite, fever, and pain in bones or the rectal, anal and pelvic area, for example—generally indicate more advanced disease.